Before you leave home
Organize sufficient travel insurance. (Flight tickets booked using a credit card, usually offers free travel insurance).
Leave your jewelry at home.
Leave a detailed itinerary with your family.
Have all the appropriate vaccinations (Hepatitis A, Meningitis and Typhoid are currently recommended).
Carry Motilium, or equivalent, for that possible upset tummy.

Luggage
A lockable suitcase is the best.
Split your clothing, copies of passports, and toiletries between 2 cases. If one case goes astray, you'll have back up.

Dress Code
Central Asians attire fluctuates from the shortest of short skirts, to traditional salwar - kameez.
The closer you travel to rural areas, the less skin you will see, therefore leave your minuscule lacy blouses and brief shorts at home.
Local men always wear long trousers.
Keep a light scarf in your bag, to cover your shoulders if requested to, whilst visiting a holy site.

Photography
Always ask before taking photographs of people.
Refrain from taking photos of police.
Photography in the Metro in Uzbekistan is forbidden, but hotels do sell beautiful postcards of the metro. Public transport
Keep a metro map handy if traveling in Uzbekistan.
If using a taxi, ask the concierge to hail one for you.
Write down where you are going, then show the driver, as it is unlikely he speaks English.
Confirm price before getting into a taxi.
Always sit in the back seat.
Advise your hotel where you are going.
Use local currency.

What to keep in your back pocket
Copy of your passport.
Hotel business card with telephone number.

AND....
Change your traveler's checks, or dollars in the hotel.
Do not be tempted to change money in the bazaar. Don't drink tap water, rather carry bottled water.
Watch a local. They carry their belongings in an advertised plastic packet.
SMS and message answering does not work in Uzbekistan.